منابع مشابه
Midazolam: an Improved Anticonvulsant Treatment for Nerve Agent-induced Seizures
The drug midazolam has been recommended to replace diazepam as the immediate anticonvulsant treatment for nerve agent-induced seizures. This recommendation marks the latest decision in an ongoing program to improve medical countermeasures to treat nerve agent poisoning. Extensive rodent screening studies first identified midazolam as the most promising compound to focus on for advanced testing....
متن کاملStudy of antiepileptic drug fosphenytoin; a prodrug of phenytoin prodrug fosphenytoin
Fosphenytoin, the disodium phosphate ester of 3‒ hydroxymethyl‒5,5‒diphenylhydantoin (FPHT/ACC 9653/Cerebyx), phosphate ester pro‒drug of phenytoin, 5,5‒diphenylhydantoin (PHT/ Dilantin), was developed to overcome complications associated with parenteral PHT administration in treatment of seizures, short‒term prophylaxis and treatment of repetitive or prolonged seizures and status epilepticus (...
متن کاملNew derivatives of benzylamide with anticonvulsant activity.
Previously obtained picolinic acid benzylamide is a potent anticonvulsant with low neurotoxicity. In search for new effective anticonvulsants twelve new benzylamides (1-12) were synthesized and preliminary evaluated in the Anticonvulsant Screening Program (ASP) of Antiepileptic Drug Development Program (ADDP) of NIH. Two of them appeared the most promising: 1-cyclopentenecarboxylic acid benzyla...
متن کاملAnticonvulsant Agents
the only anticonvulsant labeled for the treatment of both postherpetic neuralgia and diabetic peripheral neuropathy. Valproic acid and topiramate are approved for the prevention of migraine headaches. Phenytoin is not frequently used to treat neuropathic pain due to its narrow therapeutic range, adverse effects and lack of demonstrated efficacy. In general, anecdotal reports have suggested that...
متن کاملUtilization of Fosphenytoin for Digoxin-Induced Ventricular Arrhythmia
Though digoxin has been used for over 200 years, its properties and benefits continue to be investigated. Digoxin inhibits the sodium-potassium ATPase pump, thereby increasing intracellular sodium-calcium exchange in the cardiac myocyte. The resultant increase in intracellular calcium causes increased contractility. Digoxin also exerts an anti-adrenergic action in patients with heart failure by...
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ژورنال
عنوان ژورنال: Baylor University Medical Center Proceedings
سال: 1996
ISSN: 0899-8280,1525-3252
DOI: 10.1080/08998280.1996.11929985